Ketamine Infusion for Depression: Cost, Insurance and Finding a Clinic

Ketamine infusions are used off-label for depression that has not responded to other treatment, and for some chronic pain. They are not a first-line treatment, and they are not right for everyone.
Why It Is Usually Self-Pay
IV ketamine is not FDA approved for depression, so most insurers do not cover it. Clinics charge cash per infusion, and many sell a package for the starting series. Spravato, a nasal spray related to ketamine, is FDA approved for treatment-resistant depression and is more often covered.
What to Ask a Clinic
- Who gives the infusion and who monitors me?
- What is the total price for the starting series, and for boosters?
- Do you need a referral or records from my psychiatrist?
- How do you work with my therapist or psychiatrist afterward?
What a Visit Is Like
You rest in a quiet room with your heart rate, blood pressure and oxygen monitored. The drip usually lasts about 40 minutes, then you recover until the effects wear off. You cannot drive afterward.